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4th June 2010 : "Neglected microorganisms of intestinal flora: Role of yeasts and phages in IBD"

workshop - DigestScience

Meeting organized between the most renowned international experts in the field :

Yeasts areubiquitous in the human body, and although most of them are beneficial, this is not the case for Candidaalbicans, which has adapted to the digestive tract and is a dreadedopportunistic pathogen responsible for nosocomial infections with high morbidityand mortality.  Recent studies havedemonstrated its role in the evolution of inflammatory bowel disease.

While new antifungals have been developed,and although considerable progress has been made in elucidating its structure,its mechanisms of virulence, its interaction with the immune system and  the conditions necessary for its becominginvasive, much remains to be discovered concerning mutual regulation between C.albicans and the digestive tract.

Viruses arethe most numerous  biological entities onthe planet.  Phages, or viruses whichtarget bacteria, play an essential  rolein microbial balance.

While ithas been demonstrated that the digestive mucous membrane of individuals withCrohn’s disease contains significantly more bacteriophages than that of healthysubjects, their role in the ecosystem balance and in the development ofinflammatory diseases has not been elucidated. New therapeutic pathways need to be explored.

Henri Warembourg Faculty of medicine (avenue Eugène Avinée, 59120 Loos), June 4th 2010

http://www.digestscience.com/en/les-congres.html